POLR3A and cancer: There might be a mechanistic link between cancer and the development of SSc [107]: this is due to the presence of genetic abnormalities in the RPC155/POLR3A gene in the cancer tissues from anti-RNAP3+ SSc patients (but not in cancers from other SSc patients), and of mutation-specific T-cell and B-cell immune responses cross-reacting with both mutated and wild-type RNAP3 protein [108].