When the number of co-localizing spots was counted in LEDGF/p75 KD cells (77 ± 34 spots), a significant decrease (P-value < 0.001) was observed when compared to cells with WT LEDGF expression (124 ± 48 spots) whereas in LEDGF BC cells an increase in co-localizing spots was detected (157 ± 90 spots; P-value < 0.05) due to the over-expression of the protein. Here, PSIP1 is linked to breast cancer.