Mabarki et al. reported that HAPLN1 is expressed de novo in EPCAM1−/CD56 (NCAM1)+ mesoderm‐committed progenitor cells and fibroblastic hepatocellular carcinoma cells, and during the dedifferentiation of hepatocyte‐like cells to liver progenitors. Here, HAPLN1 is linked to hepatocellular carcinoma.