The OV-infected cancer cells efficiently reactivated TILs, and TNF-α and IFN-γ (Figures 6 and S12), which are known to upregulate MHC and costimulatory molecules on the surface of tumor cells and may synergize with OV-OX40L/IL12 to prime a naive T cell. Here, TNFSF4 is linked to neoplasm.