ICAM1 and cutaneous mastocytosis: The host receptor Plasmodium falciparum erythrocyte membrane protein 1-Domain cassette 8 (PfEMP1-DC8) has been discovered as an endothelial cell protein C receptor (EPCR) on brain endothelial cells which interact with PRBC [40], as well as intercellular adhesion molecule-1 (ICAM-1), which has been demonstrated to be associated with CM development.