Here, the association of EZH2 mRNA expression with BRCA1-mutant breast cancer was further evaluated using the TCGA BRCA whole exome sequencing data set (n = 526) confirming the increased expression of EZH2 in BRCA1-mutant (n = 18), compared to BRCA1-wild type breast cancer (n = 508) (p = 0.0003; Fig. 1A, left panel). This evidence concerns the gene BRCA1 and breast cancer.