IL10 and obesity due to melanocortin 4 receptor deficiency: It has been reported that in HFD-induced obesity animal models, a single transplantation of MSCs exhibits short-term effects [76].In many clinical studies, patients were treated with multiple MSCs transplantations to obtain positive results [77, 78].Multiple injections could provide more living cells that remodel the injured site environment to promote regeneration [79].Therefore, multiple intravenous IL10-MSCs transplantations may be necessary.