As well known, HFD-induced murine obesity model has been extensively used in metabolic diseases [54, 55].In our study, we also found that HFD-induced obesity was indeed a consequence of systemic and progressive inflammation and demonstrated that the multiple administrations of MSCs overexpressing IL10 could be used as a potential clinical treatment against obesity and obesity related metabolic syndrome. The gene discussed is IL10; the disease is obesity due to melanocortin 4 receptor deficiency.