IL10 and obesity due to melanocortin 4 receptor deficiency: Clementi et al. and den Boer et al. found that HFD-fed IL10 –/– mice increased body weight and hepatic triglycerides than WT mice [56].In addition, the accumulation of adipose tissue macrophages and inflammation are the key processes in the development of systemic insulin resistance caused by obesity [57, 58].