Previous studies have reported that MSCs could secret multifaceted cytokines, growth factors, and chemokines such as IL10, PGE2, TGF-β1,EGF, BFGF, and HGF that are helpful for anti-inflammation and anti-obesity via a paracrine mechanism [64–67].In this study, MSCs moderately downregulated the phosphorylation level of JNK and reduced the expression levels of inflammatory cytokines such as IL6, IL1β, and TNFα. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.