Previous studies have reported that MSCs could secret multifaceted cytokines, growth factors, and chemokines such as IL10, PGE2, TGF-β1,EGF, BFGF, and HGF that are helpful for anti-inflammation and anti-obesity via a paracrine mechanism [64–67].In this study, MSCs moderately downregulated the phosphorylation level of JNK and reduced the expression levels of inflammatory cytokines such as IL6, IL1β, and TNFα. The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.