As a regulator of cytoskeletal dynamics in microvascular endothelial cells, ERBB3 affects vascular endothelial permeability and tight junction levels [40], indicating that MSC-CM ameliorated the damaged vascular endothelial permeability with diabetes by regulation of ERBB3. MYC induces selective splicing of signal kinase MKNK2 and is a downstream molecule of ERK signaling that regulates endothelial cell proliferation and migration, inhibition of which can promote the migration of HUVECs [41]. The gene discussed is MKNK2; the disease is diabetes mellitus.