Rather than an intermediate of the differentiation of hPSC-EB-CD144+ into hPSC-BCs (hPSC-EB-CD144+  > hPSC-BC-CD144+CD45+  > hPSC-BC-CD144−CD45+), our transcriptomic analyses suggest that hPSC-BC-CD144+CD45+ are more engaged in hematopoiesis and contain more multilineage progenitors involved in the differentiation of definitive HCs such as lymphoid cells than hPSC-BCs and that they may correspond to a population in between EL-pre-HSCs and EL-HSCs/HSCs. Here, CDH5 is linked to breast cancer.