We identified 10 miR-1248 validated target genes (Table 3) and literature data confirmed the oncosuppressive role for five of them in pediatric and/or adult gliomas, namely Cyclin-dependent Kinase Inhibitor 1A (CDKN1A), Fyn-related SRC Family Tyrosine kinase (FRK), S-methyl-5'-thioadenosine phosphorylase (MTAP), Speckle-type POZ protein (SPOP) and von Hippel-Lindau disease tumour suppressor (VHL). The gene discussed is SPOP; the disease is glioma.