Although, a few studies mentioned that interfering PI3K/AKT signaling pathway may related with pyroptosis, ferroptosis and necroptosis in non-tumor diseases like hepatic ischemia reperfusion [66], hypoxic-ischemic brain damage [67] and in cardiac myofibroblasts [68] respectively, seldom research links AKT inhibition to above non-apoptotic cell death in neoplastic disease. The gene discussed is AKT1; the disease is neoplasm.