RPTOR and Anxiety: During contextual fear conditioning, PV-Raptor-Het and PV-Raptor-Homo mice showed similar freezing responses to foot shocks relative to PV-Raptor-WT mice (n = 21 PV-Raptor-WT mice, 13 PV-Raptor-Het mice, and 15 PV-Raptor-Homo mice; Two way ANOVA F (2, 46) = 0.358, p = 0.7, Fig. 4A, B), indicating normal anxiety and sensorimotor gating in the mutant mice.