Moreover, we found that the decrease of NLRP3, ASC, N-GSDMD, cleaved caspase-1 and IL-1β proteins considerably repressed the activation of the NLRP3 inflammasome and reduced the production of downstream proinflammatory mediators in myocardial tissue, including IL-18 and IL-1β and subsequent cardiomyocyte pyroptosis, thereby mitigating MI/RI. Here, CASP1 is linked to myocardial infarction.