At present, substantial evidence indicates that NLRP3 inflammasome-mediated pyroptosis originated from NLRP3 inflammasome and activated caspase-1, as well as the maturation and secretion of IL-1β and IL-18 after MI/RI insult, which is greatly participated in the pathological process of MI/RI [12]. The gene discussed is CASP1; the disease is myocardial infarction.