showed that upregulation of MIR4435-2HG increased migration, cell proliferation, metastasis, and tumor growth in hepatocellular carcinoma cells via regulating the interaction of Y-box binding protein 1 (YBX1) with snail family transcriptional repressor 1 (SNAIL1) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)PIK3CA(. The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.