MIR4435-2HG can regulate several signaling pathways, including Wnt, TGF-β/SMAD, Nrf2/HO-1, PI3K/AKT, MAPK/ERK, and FAK/AKT/β‐catenin signaling pathways; therefore, it can lead to tumor progression. Here, MAPK1 is linked to neoplasm.