Accordingly, expression was associated with overall survival of NB patients, being a high expression of CXCR4 or MIF associated with poor overall survival of patients (P < 0.01, both), whereas a more favorable outcome was related to high expression of CD74, CXCL12, and CD44 (P < 0.01 each of them) (Fig. 2C and Additional Fig. 1B). This evidence concerns the gene CXCL12 and neuroblastoma.