Expression profiles of MIF, CXCL12, and the receptors CXCR4, CXCR2, CXCR7, CD74, and CD44 were first analyzed using an RNA sequencing (RNA-seq) dataset (GSE62564) of 498 primary NB tumor samples (Additional Fig. 1A) [24]. This evidence concerns the gene CXCL12 and neoplasm.