We noticed the constant increasing of COPB2, though not significant between adjacent stages, in the first three status of LSCC (Fig. 8b); despite the difference among early and advanced stages, the expression of RYK showed no obvious change among different tumor stages of LSCC patients; TARS expression was significantly stimulated in the stage II compared with stage I (Fig. 8b). Here, RYK is linked to neoplasm.