The POLIS receives input from the Global Polio Laboratory Network (laboratory test results), POLCASE (polio case management application; AFP and environmental sample data), POLSIA (immunization activity application; immunization, vaccination, and monitoring data), and POLGIS (population and geographical reference data), as well as POLADMIN (system administration application), and provides outputs in the form of reports, dashboards, maps and line lists. This evidence concerns the gene AFP and poliomyelitis.