To further evaluate alterations in TMEM240 hypermethylation and mRNA expression in Western breast cancer patients, we analyzed the TCGA data of the Illumina Infinium HumanMethylation450 BeadChip array for 78 breast cancer tumors, 78 matched normal tissues and 623 breast cancer tumor tissues and displayed the methylation levels in a heatmap. This evidence concerns the gene TMEM240 and breast cancer.