TMEM240 and breast cancer: Analysis of RNA sequencing data from TCGA showed that TMEM240 mRNA expression was reduced by half in 51.4% (37/72) of the breast cancer tumor tissues compared with the matched normal breast tissues (p = 0.019, Additional file 1: Fig. S4) and in 60.2% (458/761) of tumors from breast cancer patients (Table 2).