Among those annotated genes are a variety of known environmental response genes including- a probable cytochrome p450, ABC transporters, collagens, various zinc finger proteins, solute carriers, serine-threonine kinases and ion receptors, glutathione S-transferase (GST), heat shock protein 70, carbonic anhydrases and the stress response protein nhaX, and a diagnostic cancer biomarker protein Cubillin. The gene discussed is HPGDS; the disease is cancer.