KLK3 and Familial prostate cancer: Laboratory methods comprise both traditional tumour marker tests which have been validated in some malignancies, such as prostate-specific antigen (PSA) in prostate cancer, and presently still investigational liquid biopsies based on detection of different elements such as cell-free circulating tumour DNA, circulating tumour cells, microRNA or exosomes in body fluids, typically in the peripheral blood [30].