GPC4 and chronic kidney disease: GPC4 levels also significantly and independently predicted the incidence of newly diagnosed decreased eGFR (OR = 2.74 [1.82–4.14]; P < 0.001, albuminuria (OR = 1.58 [1.01–2.46]; P = 0.043, and CKD (OR = 2.16 [1.45–3.23]; P < 0.001).