ROC analysis further indicated an additional predictive value of GPC4 to a basic prediction model including baseline ACR, age, sex, BMI, blood pressure, T2DM, CRP, smoking, and the presence of CAD for incident CKD and incident eGFR < 60 mL/min/1.73 m2 (Table 3). This evidence concerns the gene CRP and type 2 diabetes mellitus.