Indeed, we focused on the proteases involved in the degradation or modification of ECM (MMP-1 and TIMP-1), the products of ECM (collagen IA1) and fibrosis-related regulatory factors, such as PDGF-BB, TGF-β1, and resistin, all of whose essential roles in liver fibrosis have been established. The gene discussed is TIMP1; the disease is Hepatic fibrosis.