CFTR and lung adenocarcinoma: Among these, expression levels of CFTR (ABCC7) showed a significant inverse correlation with overall survival in lung adenocarcinoma (logrank P = 3*10–5; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.41–0.73), an association that was confirmed in independent lung adenocarcinoma validation cohorts of smokers (logrank P = 0.0021; HR, 0.49; CI, 0.3 to 0.78) and never-smokers (logrank P = 0.0023; HR, 0.31; CI, 0.14 to 0.68).