Notably, because the most commonly used and highly proliferative lung adenocarcinoma cell line A549 does not express CFTR (Hamai et al. 2009), we used Calu-3 cells, which exhibit natural CFTR expression and thus do not require CFTR overexpression, as in previous studies (Hamai et al. 2009; Qian et al. 2021). The gene discussed is CFTR; the disease is lung adenocarcinoma.