Taken together, the results of this study align with previously found associations between DISC1 and neuronal/behavioural impairments and differences in social vs. non-social reward processing in patients with various psychiatric disorders, suggesting that the tgDISC1 animal model is sensitive to capture the altered social reward processing seen in psychiatric illness, qualifying it as a potential standard for understanding the neural and psychopharmacological basis of abnormal social behavior in mental diseases. Here, DISC1 is linked to psychiatric disorder.