In addition, Trpm6 knockout mice did not display hypomagnesaemia as is the case in the disease hypomagnesaemia with secondary hypocalcaemia (HSH) caused by mutations in Trpm6. Similar observations have been made in mice deficient in49Cnnm2, suggesting that magnesium homeostasis in mice may be differently regulated compared to man. Here, TRPM6 is linked to Hypocalcemia.