TLR7 and Hepatosplenomegaly: When the cell TLR marker was analysed with regard to the manifestations of AOSD, the patient who had arthritis [1.34 (0.18)] provided a higher TLR2 intensity than the patient who did not have arthritis [1.24 (0.5), p = 0.02], and the patient who had hepatosplenomegaly [1.59 (0.04)] had a higher intensity of TLR7 than those who did not have hepatosplenomegaly [1.25 (0.29), p = 0.042] (Table 3).