SNX3 and cancer: Sequencing data in GSE66229 was normalized with log function by the data provider, and thus transcriptional levels of SNXs were all limited within 1–4, as shown in Fig. 2B. Clustering analysis between cancer and normal tissue showed differentially expression of SNX members intuitively, as shown in Fig. 2C. Corresponding to beeswarms, clustering analysis in Fig. 2D dictates a highest transcriptional level of SNX3, and then SNX2/4/5/6/7/9/12/17, SNX15/20/22/31/32 extremely low expressed and then SNX13/16/21/24/25/29/30, SNX1/8/10/11/14/18/27/33 transcribed at a middle level.