In the 10th patient, two genetic variants were detected simultaneously, namely, WWOX and ATP7A. The clinical phenotypes of WWOX gene reported in the literature were autosomal recessive epileptic encephalopathy, early infantile 28, esophageal squamous cell carcinoma, somatic and spinocerebellar ataxia, and autosomal recessive 1216,17. Here, WWOX is linked to esophageal squamous cell carcinoma.