SOD1 and amyotrophic lateral sclerosis: Strikingly, among two hundred and sixteen genetic mutations of SOD1 identified from different familial ALS1–5,8,17–22,25,26,29,44–50 (https://alsod.iop.kcl.ac.uk/), one hundred and eighty-two clinically identified mutations are located within the SOD1 fibril core structure determined in this study, in which one hundred and five representative genetic ALS-related mutations are listed in Fig. 4a.