Recent studies confirm the relevance of Pla2g7 for shaping the immune phenotype in humans and mice.2–4 Lp-PLA2 (encoded by Pla2g7) levels were investigated as a possible biomarker in chronic obstructive pulmonary disease (COPD), a disease indicative for accelerated aging. This evidence concerns the gene PLA2G7 and chronic obstructive pulmonary disease.