We performed global lipidomic profiling in two cell lines after 24 h of infection (Fig. 1A and Supplementary Fig. 1): HEK293T cells overexpressing the ACE2 protein (HEK293T-ACE2), in order to be able to correlate the results with viral-protein-transfected cells, and the more physiologically relevant cell type A549-ACE2 cells, to model the cells affected in natural infection. This evidence concerns the gene ACE2 and infection.