PLEKHA7 and hypertensive disorder: A mechanism through which PLEKHA7 could modulate blood pressure is the regulation of calcium homeostasis, since depletion of the PLEKHA7 homolog heart adapter protein 1 (Hadp1) in zebrafish alters cardiac contractility (13), and PLEKHA7 mutant rats exhibit attenuated hypertension in response to a high salt diet (14), correlating in both cases with altered calcium handling.