As shown in Fig. 2, cHDL isolated from chow-fed mice and lean human subjects (hHDL), expected to lack atherosclerosis and systemic inflammation, completely blocked gene expression of chemokines serum amyloid A3 (Saa3), monocyte chemotactic protein 1 (Ccl2), and the cytokine interleukin 1-beta (Il1b) induced by PA, whereas HDL from mice that had been injected with inflammatory silver nitrate (AgNO3) had no effect, as we have shown previously (22). The gene discussed is SAA3P; the disease is atherosclerosis.