IL1B and atherosclerosis: As shown in Fig. 2, cHDL isolated from chow-fed mice and lean human subjects (hHDL), expected to lack atherosclerosis and systemic inflammation, completely blocked gene expression of chemokines serum amyloid A3 (Saa3), monocyte chemotactic protein 1 (Ccl2), and the cytokine interleukin 1-beta (Il1b) induced by PA, whereas HDL from mice that had been injected with inflammatory silver nitrate (AgNO3) had no effect, as we have shown previously (22).