We have previously shown that male mice deficient in the LDL receptor (Ldlr) that had been rendered obese while consuming a high-fat high-sucrose (HFHS) diet, a model that closely approximates human metabolic syndrome (9), lose significant body weight and fat mass when supplemented with 10,12 CLA for 8 weeks (10). The gene discussed is LDLR; the disease is metabolic syndrome.