FOXG1 and Zika virus infectious disease: We demonstrate that (1) FOXG1 is displaced from the nucleus to the cytoplasm and downregulated following ZIKV infection; (2) it is a specific target of ZIKV, but not of other Arboviruses, such as Usutu virus (USUV) and Chikungunya virus (CHIKV); (3) its C-terminal domain is responsible for mediating FOXG1 mislocalization; and (4) FOXG1-targeted genes are altered following ZIKV infection, thus defining a causal link between ZIKV, FOXG1, cortical NSC vulnerability, cell cycle alteration, and cell death.