Given that GFs prevented the effect of ZIKV infection on FOXG1 nuclear displacement and AKT signaling is pivotal for FOXG1 functional activation and intracellular localization (Baek et al., 2015; Dastidar et al., 2011), we molecularly dissected the activity of FOXG1 domains. The gene discussed is FOXG1; the disease is Zika virus infectious disease.