A long-term influence of automatic attentional guidance by LPL (Jiang et al., 2013b) is effective regardless of the developmental trajectory (Jiang et al., 2016; Lee et al., 2020; Sisk et al., 2018), search space scale (Sisk et al., 2021; Smith et al., 2010; Won et al., 2015), cognitive impairment with working memory load (Won & Jiang, 2015) or cognitive deficits (Sisk et al., 2018). The gene discussed is LPL; the disease is Cognitive impairment.