We showed that the rs77768175 AA genotype, rs2074356 GG genotyp,e and rs11066280 TT genotype in HECTD4 were associated with significantly increased risks of diabetes (by 1.839, 1.746, and 1.723 in the HEXA group and by 1.719, 1.787, and 1.659 in the Ansan–Ansung group, respectively) in drinkers. Here, HEXA is linked to diabetes mellitus.