Multivariate Cox regression analysis, including VAF of the TERT c.-124C > T mutation, CTC number at 12 months and pathological stage as covariables, identified CTC number 12 months after RC as an independent prognostic biomarker for tumor progression (HR 1.020; p = 0.009) and CSS (HR 1.021; p = 0.021). This evidence concerns the gene TERT and neoplasm.