Our findings suggest that in treatment-experienced patients with virologically controlled HIV infection and a high CD4+ T-cell count, especially those with a long history of HIV infection, more than 48 weeks are needed to evaluate the significant changes in the CD4/CD8 ratio after switching.[25] Moreover, the impact of dual therapy on the restoration of the immune system could differ depending on the antiretrovirals used, including INSTIs, boosted PIs,[23] and NNRTIs. This evidence concerns the gene CD4 and HIV infectious disease.