TMEM106A and hepatocellular carcinoma: To explore the role of TMEM106A in HCC progressionin vitro andin vivo, we established stable TMEM106A-knockdown Hep G2 and PLC/PRF/5 cells (Figure 5A), as well as stable TMEM106A-overexpressing MHCC97H and HCCLM3 cells (Supplementary Figure S1A).In vitro, enhanced proliferative capacity was observed after downregulation of TMEM106A expression in PLC/PRF/5 and Hep G2 cells (Figure 5B).