TMEM106A and hepatocellular carcinoma: TMEM106A expression was increased at the mRNA and protein levels in the poorly metastatic HCC cell lines (PLC/PRF/5, Hep G2, and Huh7), compared with that in the highly metastatic HCC cell lines (MHCC97L, MHCC97H, and HCCLM3;P<0.001;Figure 1A).