Moreover, using a median cutoff for TMEM106A methylation in tumors (higher than median level=hypermethylation, and lower than median level=hypomethylation), the 5-year OS of TMEM106A-hypermethylated HCC patients was significantly lower than that of the TMEM106A-hypomethylated patients (P=0.0082;Figure 2B). Here, TMEM106A is linked to hepatocellular carcinoma.