Prior studies suggest that neuronal loss, astroglial activation, down‐regulation of brain‐derived neurotrophic factor (BDNF), disruption of blood–brain barrier, and brain hypoxia contribute to delirium pathophysiology.[36, 37, 38, 39, 40] We tested whether these factors are involved in E4bp4 regulation of delirium. Here, NFIL3 is linked to delirium.