Supporting this, mice with E4bp4 specifically deleted in microglia (generated by breeding mice carrying a conditional E4bp4 allele with mice expressing Cx3cr1CreER, named microgliaE4bp4‐KO mice[35]) showed aggravated delirium‐associated cognitive decline, as evidenced by a slower recovery based on the NOR and Y maze tests (Figure 5G,H). This evidence concerns the gene NFIL3 and Mental deterioration.