For inflammation in the CRS‐stimulated rats, LY294002 increased SGKL‐inhibited levels of TNF‐α, IL‐1β, and IL‐6 (Figure 7H, F1 = 33.62, p < 0.0001, F2 = 25.74, p < 0.0001, F3 = 22.61, p < 0.0001; Figure 7I, F1 = 49.60, p < 0.0001, F2 = 46.06, p < 0.0001, F3 = 28.81, p < 0.0001; Figure 7J, F1 = 15.93, p < 0.0001, F2 = 24.64, p < 0.0001, F3 = 40.52, p < 0.0001;), suggesting that the PI3K/Akt/mTOR pathway mediated SGKL‐regulated inflammation in CRS‐stimulated rats. The gene discussed is SGK3; the disease is congenital rubella syndrome.