Moreover, we concluded that Parasutterella, Aeromonas, Ruminococcaceae_UCG_008, Globiocatella, Shuttleworthia, and Clostridium_sensu_stricto_1 were the biomarkers of depression, and Candidatus Arthromitus might be the therapeutic target of SGKL during improving depressive‐like behaviours. The gene discussed is SGK3; the disease is depressive disorder.