In this study, we performed interventional studies to elucidate whether celecoxib ameliorates hepatosteatosis induced by enhanced de novo lipogenesis in mice with hepatic overexpression of activated v‐akt murine thymoma viral oncogene homologue (AKT),12 as well as in fructose‐fed mice featuring steatosis of hepatocytes driven by an Akt‐independent lipogenic cascade.13 Here, AKT1 is linked to steatosis.