In accordance with previous studies elucidating the molecular mechanisms by which celecoxib obstructs the evolution of liver cancer,19, 31, 32 we observed that celecoxib suppressed the Akt/mTORC1 signalling that plays a decisive role in governing de novo lipogenesis by potentiating the efficiency of lipogenic gene networks in the Akt mice. This evidence concerns the gene AKT1 and liver cancer.