The levels of G6PD and PDCD1 (r=0.387, P<0.001), CD274 (r=0.157, P=0.002), and CTLA4 (r=0.439, P<0.001) were positively correlated in HCC (Figure 4), suggesting that G6PD in HCC affects the efficacy of immunotherapy. Here, PDCD1 is linked to hepatocellular carcinoma.