In summary, we report that HLA‐A*02:01 and HLA‐A*11 are associated with a risk of disease recurrence after radical prostatectomy independent of Gleason score, s‐PSA and T‐stage in a cohort with low‐intermediate risk and a high‐risk prostate cancer cohort, respectively. The gene discussed is KLK3; the disease is Familial prostate cancer.