ALDH2 also plays a key role in improving detoxification of reactive aldehydic products arising from lipid peroxidation under oxidative stress, such as 4‐hydroxy‐2‐nonenal (4HNE) and malondialdehyde (MDA), thus exerting a protective effect against acute (ischaemia) and chronic (heart failure) cardiovascular diseases.48, 49. This evidence concerns the gene ALDH2 and heart failure.