NFKB1 and cancer: Genes of cluster 4 were enriched in inflammation and cancer related processes, such as NF‐κB pathway (Figure 4D,E), which has been proved to be critical for colitis‐associated CRC.[4] Genes of cluster 8 were enriched in processes related with lipid metabolism and PKA signaling, which is also involved in CRC (Figure S6F,M, Supporting Information).[20] Our analysis suggested that the information of histone modifications on function chromatin elements can be used to identify functional gene sets.