They are involved in the suppression of immune response, and their deficiency leads to increased susceptibility to colitis; but controversial evidence exists for their roles in colorectal cancer.[26, 27] Our data suggest that Otx2 possibly represses colitis‐associated CRC through mediating the transcription of tumor suppressive genes, such as IFITM family genes. The gene discussed is OTX2; the disease is colorectal cancer.