Meanwhile, PDPA protonation is also expected to promote the endosomal escape of 1) cGAMP that needs to bind with and activate cytosolic STING, and 2) MHC‐I‐restricted neoantigens that need to be processed by proteases and complexed with MHC‐I in the cytosol prior to antigen cross‐presentation to elicit CD8+ T‐cell responses.[25] Further, cGAMP delivered by NVs triggered IFN‐I‐driven inflammation to drive neoantigen cross‐presentation and reprogram the tumor immune microenvironment. The gene discussed is CD8A; the disease is neoplasm.