While the role of lamin A/C in limiting nuclear deformation and passage through confining channels has been studied extensively in pores and microchannels with a smooth contiguous surface, cells such as fibroblasts and cancer cells encounter slender extracellular matrix fibers as they migrate through interstitial tissue.[22] Here we examined the role of lamin A/C in cell migration through discrete, closely spaced obstacles designed such that their stiffness was similar to the stiffness of single collagen fibers. This evidence concerns the gene LMNA and cancer.