saMAS1/AD significantly decreased the expression of a key lipid metabolism protein, sterol regulatory‐element binding protein (SREBP), while two markers of ER stress, binding immunoglobulin protein (BiP) and C/EBP homologous protein (CHOP), were significantly increased in ovarian cancer spheroids following treatment with saMAS1/AD complexes (Figure 4g,h). This evidence concerns the gene HSPA5 and ovarian cancer.