MAS1 and neoplasm: The RAS plays a fundamental role in multiple physiological systems and is involved in cancer progression and metastasis.[8] Dysregulation of RAS is associated with pathological conditions, and impacts on malignancy of tumors via tissue remodeling, inflammation, angiogenesis, and apoptosis.[8] Hence, targeting RAS has been proposed as a novel approach to control the tumor microenvironment as well as tumor growth and dissemination.[9] saRNAs that specifically and precisely regulate MAS1 expression could therefore offer a promising approach for treating cancer.