Given the previously discussed importance of the non-canonical inflammasome in sepsis and controling intracellular Gram-negative bacterial pathogens, these findings suggest that HO-1 limits the activation of non-canonical inflammasome signalling by modulating heme levels (Kajiwara et al., 2014; Casson et al., 2015; Deng et al., 2018). Here, HMOX1 is linked to Sepsis.