Macrophages isolated from Gpx8−/− mice post-DSS treatment expressed higher levels of pro-inflammtory cytokines (IL-1β and IL-6) and adoptive transfer of Gpx8-deficient macrophages into mice prior to DSS treatment resulted in an exacerbated colitis phenotype indicating a protective role for GPx8 in macrophages during experimental colitis (Hsu et al., 2020). Here, IL6 is linked to colitis.